George's professional life is unstable. He is unable to remain in any job for any great length of time before making an embarrassing blunder and getting fired. Very often the blunder is lying and trying to cover it up only to have it all fall apart.
Over the course of the series, he works for a real estate transaction services firm (Rick Bahr Properties), Elaine's company (Pendant Publishing), the New York Yankees (his longest running job), a playground equipment company (Play Now), an industrial smoothing company (Kruger Industrial Smoothing), and other places. He is fired from his job at Pendant Publishing for having sex with the cleaning woman on his desk in "The Red Dot" (he professes he is always been attracted to cleaning women).
His original job when the series starts is as a real estate agent; he ends up quitting, only to slip his boss a mickey in "The Revenge". It remains to be seen why George would be able to collect unemployment when he quit his job without any good reason. He always wanted to pretend that he was an architect; he first designs to be one in "The Stakeout", and he claims in "The Race" that he had designed "the new addition to the Guggenheim." In "The Van Buren Boys", he denies his young protégé a scholarship from the Susan Ross Foundation when the young man decides he no longer wants to be an architect, and wants to become a city planner instead. In "The Marine Biologist", Jerry tells a girl George wanted to impress that George is a marine biologist. The plan backfires when George is called upon to save a beached whale with a Titleist golf ball in its blowhole; he saves the whale, but the woman tells him off when he confesses that he is not, in fact, a marine biologist.
During the fourth season of the series, George gains experience as a sitcom writer as he helps Jerry to write the pilot for the fictitious show Jerry. While pitching the concept of a "show about nothing" to NBC executives, George claims to have written an off-off-Broadway play entitled La Cocina, about a Mexican chef named Pepe. George claims Pepe mimed the preparation of tamales, and it was the mime aspect that made the play so funny.